Treating Sickle Cell Pain Crisis

Summary:  The sickle cell patient can have the chronic sickle cell pain crisis. There is an uncertainty in the etiology of the chronic sickle cell pain crises. The severity sickle cell pain crises can change over time and varies greatly. By the intermittent usage of the mild analgesics, some patients can overcome their sickle cell pain crises. Other patients required the frequent usage of the opiod analgesics. Consequently, there is not universal formula is available for the management of the sickle cell pain crises. Therefore, it is the biggest challenge for the physicians to manage the sickle cell pain crises.


Content: Nonsteroidal anti-inflammatory drugs can be effective in controlling the sickle cell pain crises in many of the patients. These agents can be used with the opiod analgesics. To control flairs of pain, the NSAIDs are one common type of the medicine. These types of the medicine can cause the renal damage. The sickle cell patients can have the renal injury, as they are more susceptible than normal people. Therefore, the physicians must narrowly monitor the renal function in patients with these types of the drugs. Cox 2 inhibitors generate less nephrotoxicity than the normal NSAID’s.


The use of these agents has proven effective in some of the experiences to control sickle cell pain crises in the people with sickle cell disease. Some of the patients under severe condition require the frequent doses of opiods to control the sickle cell pain crises. There is a chance for the sickle cell patient to become tolerant to the opiods. A blunt the severity of the pain is observed in the case of long-acting opiod analgesics. A suitable treatment of the sickle cell pain crises in spite of the cause requires a serious dialogue between the doctor and the patient.


It is good to talk with the analgesics; no matter you have mild sickle cell pain crises or the severe. The patients can afford the severe sickle cell pain crises, as these can become unbearable in no time. It is better to control the intensity of the pain from the tolerable level than controlling it from the highest level. In the typical episode of the severe sickle cell pain crises a patient can use the four to eight mg of the oral hydromorphone every 3 hours. Many severe sickle cell pain crises are manageable at home, by resting relaxing and using lots of the fluid. The patient must seek emergency medical care, if the pain progresses in spite of taking the reasonable quantity of the medication.

A lot of of the health care providers do not understand that severe chronic sickle cell pain crises can also be a consequence of sickle cell disorder. Sickle cell pain crises occur more commonly in adults. The short duration of action is the main hurdle in managing the sickle cell pain crises, like in the case of hydromorphone and the meperidine.


There are numbers of the long acting medicine are also available, like the methadone. It is very effective drug in controlling the sickle cell pain crises. The proper guideline is necessary for use of any opiod, the same is the use with the use of Methadone. Meperidine has some side effects; the half life of the drug is about four hours, the liver is the place where the meperidine is converted to the normeperidine, this derivative has the pain relieving activities but also some toxicity. The Grand mal seizure is the serious side effect of using the amounts of meperidine. Normeperidine can cause the serious damage in this situation. The American Pain Society has already prohibited the usage of the meperidine in controlling the sickle cell pain crises of the people who required longer term analysis.

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